He married Frances Mottrom . Frances Mottrom was born at Coan Hall, Northumberland, Virginia Abt 1645 daughter of John Mottrom and Mary Taylor .
They were the parents of 6
children:
Nicholas Spencer
born Abt 1664.
Mottrom Spencer
born Abt 1666.
Elizabeth Spencer
born Abt 1667.
John Spencer
born Abt 1669.
Francis Spencer
born Abt 1674.
William Nicholas Spencer
born 1680.